Bulimia Nervosa: Types, Causes, Symptoms, Diagnosis, Complications, and Impact on Fertility

Bulimia Nervosa: Types, Causes, Symptoms, Diagnosis, Complications, and Impact on Fertility


Highlights Of Bulimia Nervosa

  1. Bulimia nervosa is a serious eating disorder characterized by cycles of binge eating followed by purging behaviors like vomiting or excessive exercise to avoid weight gain.
  2. People with bulimia often experience a sense of losing control during binge eating episodes. They may eat large amounts of food in a short period, which brings temporary relief, followed by intense guilt, shame, or fear of weight gain.
  3. The disorder can lead to electrolyte imbalances, severe dental issues, anxiety, and depression.
  4. Bulimia can affect anyone, but it is most commonly diagnosed in teenage girls and young women. However, men and older adults can also be affected, and the condition can go undetected due to stigma and secrecy.
  5. Recovery from bulimia is possible, but it requires early intervention and consistent support.

What is Bulimia Nervosa?

Bulimia nervosa is a significant eating disorder marked by recurrent episodes of eating unusually large amounts of food in a short time, followed by efforts to counteract the overeating through purging (vomiting), using laxatives, or engaging in extreme physical exercise. [1] Feelings of distress and loss of control accompany these episodes. The disorder can severely affect your physical health, causing electrolyte imbalances, damage to your gastrointestinal tract, and serious dental problems. It is estimated that bulimia nervosa affects 1-2% of young women worldwide, though the actual numbers might be higher due to underreporting. [2]

Types of Bulimia nervosa

1. Purging type

People in this category use self-induced vomiting or misuse laxatives, diuretics, or enemas to eliminate consumed food. The frequent vomiting exposes the body to harmful stomach acids, which can have lasting consequences, such as damage to the esophagus and tooth enamel. [3]

2. Non-Purging type

Instead of vomiting, individuals may engage in compensatory behaviors like excessive exercise, fasting, or strict dieting. These activities prevent weight gain and are just as harmful, putting the body under significant physical strain. [3]

Who is at Risk of Bulimia Nervosa?

Bulimia nervosa impacts more women than men, affecting up to 2% of women across all racial and ethnic backgrounds. [2] Teenage girls between 15 and 19, as well as young women in their early 20s, are the most vulnerable group. [2] However, there’s a rising trend of eating disorders occurring in older women too. A study found that 13% of American women over 50 had signs of an eating disorder. [2]

Causes and Risk Factors of Bulimia Nervosa

Bulimia nervosa is a complex eating disorder influenced by a combination of psychological, biological, and social factors. Understanding the causes and risk factors of bulimia is essential to identifying those at risk and providing effective support and treatment.

Risk of Bulimia Nervosa

1. Genetics and family history

If you have a relative with an eating disorder, your risk is higher. Research shows that genetic variations may make some people more vulnerable to developing bulimia. [4]

2. Psychological factors

Mental health issues, including low self-esteem, perfectionism, impulsive behavior, and anxiety disorders, are closely associated with bulimia. These psychological struggles often worsen the cycle of binge eating and purging. [4]

3. Cultural and societal pressure

Living in a society that idealizes thinness can have a powerful impact. The constant exposure to body image standards through social media and advertisements can trigger unhealthy attitudes toward food and body shape. [5]

4. Trauma and stressful life events

Experiencing trauma, abuse, or high levels of stress can be a catalyst for developing bulimia. Coping with major life changes, like moving to a new place or dealing with the death of a loved one, can also increase the risk. [6]

5. Dieting and body image obsession

Dieting is a common trigger for bulimia. Restrictive eating can lead to a feeling of deprivation, making it more likely that you’ll binge eat. People who are overly focused on their body weight are especially vulnerable. [4]

Signs and Symptoms of Bulimia Nervosa

Recognizing the signs and symptoms of bulimia nervosa is crucial for early intervention and effective treatment. Understanding these warning signs can help support those struggling with this condition.

Symptoms of Bulimia Nervosa

1. Binge eating episodes

People may consume large amounts of food in a short period, often feeling out of control during these binges. The food is typically high in calories and easy to eat quickly, like snacks or desserts. This behavior is usually done secretly, adding to feelings of shame and isolation. [7]

2. Purging behaviors

To compensate for the binges, they might induce vomiting, misuse laxatives, or engage in excessive exercise. These actions prevent weight gain but can severely damage the body over time. [7]

3. Weight fluctuations

People with bulimia often maintain a normal or near-normal weight, but frequent weight changes may still occur. This can make it difficult to detect and mask the severity of the disorder. [8]

4. Preoccupation with body image

A persistent fear of gaining weight and an obsession with body shape are common. They may feel extreme dissatisfaction with their body, which worsens the cycle of unhealthy eating behaviors. [7]

5. Oral signs

There might be swollen cheeks or jaw areas from enlarged salivary glands, chronic sore throat, and acid reflux. Teeth may show enamel erosion, leading to increased cavities and tooth sensitivity. [9]

6. Calluses or scars on knuckles

These are sometimes referred to as “Russell’s sign,” resulting from using hands to induce vomiting. The skin on the knuckles may become rough or scarred from repeated contact with teeth. [10]

7. Gastrointestinal issues

People may experience bloating, constipation, or abdominal pain due to disrupting normal digestion and using laxatives or other purging methods. These symptoms can become chronic and interfere with daily life. [11]

8. Emotional and behavioral symptoms

Mood swings, irritability, and withdrawal from friends or family can occur. They may also exhibit signs of anxiety, depression, or obsessive-compulsive behaviors, which can be both causes and consequences of bulimia. [7]

Complications of Bulimia Nervosa

Bulimia nervosa can lead to a range of severe complications that affect both physical and mental health. Recognizing these complications highlights the importance of timely treatment and support.

Complications of Bulimia Nervosa

 

1. Electrolyte imbalances

Vomiting and laxative abuse can lower your potassium, sodium, and calcium levels. These imbalances can cause irregular heartbeats and even lead to heart failure or sudden death. [12]

2. Gastrointestinal issues

Repeated vomiting can cause chronic sore throats, inflammation of the esophagus, and a condition known as acid reflux. Laxative abuse can lead to long-term colon damage and constipation. [13]

3. Tooth decay and oral health problems

Stomach acid from vomiting can erode your teeth’s enamel, increasing your risk of cavities, tooth sensitivity, and gum disease. You might also experience swollen salivary glands, which can alter your face’s appearance. [9]

4. Kidney damage

The strain caused by severe dehydration and the constant disruption of electrolyte levels can impair kidney function, sometimes permanently. [12]

5. Mental health complications

Bulimia often coexists with mood disorders like depression and anxiety. Substance abuse is also more common in people with bulimia, further complicating treatment and recovery. [14]

Diagnosis of Bulimia Nervosa

The diagnosis of Bulimia Nervosa is entirely clinical. Some of the tests are done to assess the effect of the condition on the body.

Diagnosis of Bulimia Nervosa

1. Physical examination

Your doctor can look for physical signs of bulimia, such as swollen glands, dental issues, and calluses on your hands from induced vomiting.

2. Psychological evaluation

A mental health specialist will discuss your eating behaviors, attitudes toward body weight, and emotional state. This step is crucial to understanding the severity and root causes of the disorder. [14]

3. Blood and urine tests

These tests check for nutritional imbalances, dehydration, and electrolyte abnormalities. They also help assess the disorder’s overall impact on your organs. [15]

4. Electrocardiogram (ECG)

Since bulimia can affect heart health, an ECG may monitor your heart’s rhythm and function.  [15]

5. Bone Density Scan

A bone scan detects osteoporosis or bone thinning, especially if there is severe or long-standing malnutrition. [16]

Treatment of Bulimia Nervosa

Effective treatment for bulimia nervosa involves:

Treatment of Bulimia Nervosa

1. Cognitive Behavioral Therapy (CBT)

This therapy helps you change negative thought patterns related to food and body image. CBT teaches practical coping strategies and emphasizes the importance of developing a healthy relationship with food. [17]

2. Nutritional rehabilitation and counseling

Dietitians work with you to create a balanced meal plan that eliminates the cycle of bingeing and purging. They also educate you on the importance of proper nutrition for overall well-being. [18]

3. Medication

Antidepressants, particularly SSRIs like fluoxetine (Prozac), can be effective in reducing binge-purge cycles and managing co-occurring depression or anxiety. It is the only medication approved by the Food and Drug Administration (FDA) for treating bulimia in adults. However, these medications work best when combined with therapy. [19]

4. Family-Based Therapy

This approach involves family members in the treatment process, especially for adolescents. Families learn to support the individual without judgment and help them build healthier habits. [20]

5. Hospitalization and inpatient programs

In severe cases, hospitalization may be needed to address medical complications and stabilize weight. Inpatient programs offer intensive therapy and a structured environment for recovery. [21]

Effect of Bulimia Nervosa on Fertility

Bulimia nervosa can significantly impact fertility, as the disorder often disrupts normal reproductive function. Frequent bingeing and purging behaviors can lead to nutritional deficiencies, hormonal imbalances, and irregular menstrual cycles, which make it more difficult for someone to conceive. Chronic stress and extreme fluctuations in weight further impair reproductive health, affecting the body’s ability to support a healthy pregnancy. Additionally, the physical strain of bulimia may reduce ovarian function and affect the quality of eggs released during ovulation. [22]

Questions to Ask Your Doctor

  1. What strategies can I use to manage my urge to binge eat?
  2. How can I ensure I’m getting the proper nutrients without feeling overwhelmed?
  3. Is there a support group or community resource you recommend for ongoing encouragement?
  4. What lifestyle changes should I make to support my treatment and recovery?
  5. How do I involve my friends and family in my recovery without feeling judged?
  6. Do I need any supplemental vitamins?

References

  1. Jain A, Yilanli M. Bulimia Nervosa [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2023. Available from: https://www.ncbi.nlm.nih.gov/books/NBK562178/
  2.  Gagne DA, Von Holle A, Brownley KA, Runfola CD, Hofmeier S, Branch KE, et al. Eating disorder symptoms and weight and shape concerns in a large web-based convenience sample of women ages 50 and above: results of the Gender and Body Image (GABI) study. The International Journal of Eating Disorders [Internet]. 2012 Nov 1;45(7):832–44. Available from: https://www.ncbi.nlm.nih.gov/pubmed/22729743
  3. Jordan J, McIntosh VVW, Carter JD, Rowe S, Taylor K, Frampton CMA, et al. Bulimia nervosa-nonpurging subtype: Closer to the bulimia nervosa-purging subtype or to binge eating disorder? International Journal of Eating Disorders. 2013 Nov 26;47(3):231–8. Available from:https://pubmed.ncbi.nlm.nih.gov/24282157
  4. Keski-Rahkonen A. Eating disorders: etiology, risk factors, and suggestions for prevention. Current Opinion in Psychiatry [Internet]. 2024 Aug 22 [cited 2024 Oct 22];37(6):381–7. Available from: https://pubmed.ncbi.nlm.nih.gov/39239881/
  5. ‌Yamamiya Y, Stice E. Risk factors that predict future onset of anorexia nervosa, bulimia nervosa, binge eating disorder, and purging disorder in adolescent girls. Behavior Therapy [Internet]. 2023 Oct 31;55(4). Available from: https://www.sciencedirect.com/science/article/pii/S0005789423001235
  6. Pike KM, So M, Hilbert A, Maekawa H, Shimanouchi T, Wilfley D, et al. Risk factors for anorexia nervosa and bulimia nervosa in Japan and compared to a U.S. sample. International Journal of Eating Disorders. 2020 Dec 23;54(2):155–67. Available from: https://pubmed.ncbi.nlm.nih.gov/33355934
  7. Levinson CA, Zerwas S, Calebs B, Forbush K, Kordy H, Watson H, et al. The core symptoms of bulimia nervosa, anxiety, and depression: A network analysis. Journal of Abnormal Psychology [Internet]. 2017 Apr [cited 2019 Dec 13];126(3):340–54. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5378619/
  8. Keel PK, Bodell LP, Forney KJ, Appelbaum J, Williams D. Examining weight suppression as a transdiagnostic factor influencing illness trajectory in bulimic eating disorders. Physiology & Behavior. 2019 Sep;208:112565.Available from: https://pubmed.ncbi.nlm.nih.gov/31153878
  9. Kim IH, Hong WW, Mupparapu M. A Patient Diagnosed with Bulimia Reports to the Dental Office Seeking Cosmetic Dental Work. Dental Clinics of North America [Internet]. 2023 Jun 18 [cited 2024 Nov 6];67(4):699–702. Available from: https://pubmed.ncbi.nlm.nih.gov/37714628
  10. Stamu-Obrien C, Shivakumar S, Messas T, Kroumpouzos G. Through the Looking Glass: Skin Signs that Help Diagnose Eating Disorders. Clinics in Dermatology. 2023 Mar; Available from: https://pubmed.ncbi.nlm.nih.gov/36878454
  11. Riedlinger C, Schmidt G, Weiland A, Stengel A, Giel KE, Zipfel S, et al. Which Symptoms, Complaints and Complications of the Gastrointestinal Tract Occur in Patients With Eating Disorders? A Systematic Review and Quantitative Analysis. Frontiers in Psychiatry [Internet]. 2020 Apr 20;11(195). Available from:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212454/
  12. Nitsch A, Dlugosz H, Gibson D, Mehler PS. Medical complications of bulimia nervosa. Cleveland Clinic Journal of Medicine. 2021 Jun;88(6):333–43. Available from: https://pubmed.ncbi.nlm.nih.gov/34078617
  13. Bern EM, Woods ER, Rodriguez L. Gastrointestinal Manifestations of Eating Disorders. Journal of Pediatric Gastroenterology & Nutrition. 2016 Nov;63(5):e77–85. Available from: https://pubmed.ncbi.nlm.nih.gov/27579693
  14. Himmerich H, Hotopf M, Shetty H, Schmidt U, Treasure J, Hayes RD, et al. Psychiatric comorbidity as a risk factor for the mortality of people with bulimia nervosa. Social Psychiatry and Psychiatric Epidemiology [Internet]. 2019 Feb 11 [cited 2019 Dec 19];54(7):813–21. Available from: https://link.springer.com/article/10.1007/s00127-019-01667-0
  15. Harrington. Initial evaluation, diagnosis, and treatment of anorexia nervosa and bulimia nervosa. American family physician [Internet]. 2015 [cited 2024 Nov 6];91(1). Available from: https://pubmed.ncbi.nlm.nih.gov/25591200/
  16. Robinson L, Aldridge V, Clark EM, Misra M, Micali N. A systematic review and meta-analysis of the association between eating disorders and bone density. Osteoporosis International. 2016 Jan 18;27(6):1953–66. Available from: https://pubmed.ncbi.nlm.nih.gov/26782684
  17. Glasofer DR, Devlin MJ. Cognitive behavioral therapy for bulimia nervosa. Psychotherapy. 2013;50(4):537–42. Available from: https://pubmed.ncbi.nlm.nih.gov/24295463
  18. Hackert AN, Kniskern MA, Beasley TM. Academy of Nutrition and Dietetics: Revised 2020 Standards of Practice and Standards of Professional Performance for Registered Dietitian Nutritionists (Competent, Proficient, and Expert) in Eating Disorders. Journal of the Academy of Nutrition and Dietetics. 2020 Nov;120(11):1902-1919.e54.Available from: https://pubmed.ncbi.nlm.nih.gov/33099403
  19. Aikaterini Argyrou, Lappas AS, Dimitra Rafailia Bakaloudi, Eirini Tsekitsidi, Elissavet Mathioudaki, Michou N, et al. Pharmacotherapy compared to placebo for people with Bulimia Nervosa: A systematic review and meta-analysis. Psychiatry Research-neuroimaging. 2023 Sep 1;327:115357–7. Available from: https://pubmed.ncbi.nlm.nih.gov/37562154
  20. Valenzuela F, Lock J, Le Grange D, Bohon C. Comorbid depressive symptoms and self-esteem improve after either cognitive-behavioural therapy or family-based treatment for adolescent bulimia nervosa. European Eating Disorders Review. 2018 Feb 15;26(3):253–8. Available from: https://pubmed.ncbi.nlm.nih.gov/29446174
  21. Hagan KE, Walsh BT. State of the Art: The Therapeutic Approaches to Bulimia Nervosa. Clinical Therapeutics [Internet]. 2021 Jan 1 [cited 2021 Jun 17];43(1):40–9. Available from: https://www.clinicaltherapeutics.com/article/S0149-2918(20)30483-5/fulltext
  22. Micali N, dos-Santos-Silva I, De Stavola B, Steenweg-de Graaf J, Jaddoe V, Hofman A, et al. Fertility treatment, twin births, and unplanned pregnancies in women with eating disorders: findings from a population-based birth cohort. BJOG: An International Journal of Obstetrics & Gynaecology. 2013 Oct 30;121(4):408–16. Available from: https://pubmed.ncbi.nlm.nih.gov/24206173

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